Publications - Postdoctoral, Graduate, and Undergraduate
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16. “Synthesis and characterization of high affinity fluorogenic α-synuclein probes.” Z. Zhand-Lengyel, J. J. Ferrie, B. Janssen, C.-J. Hseih, G. Thomas, K. Xu, C. M. Haney, V. M.-Y. Lee, J. Q. Trojanowski, E. J. Petersson, R. Mach, Chemical Communications, 2020, 56, 3567. Link
15. “Cyclized NDGA modifies dynamic α-synuclein monomers, preventing aggregation and toxicity.” M. J. Daniels, B. Nourse, H. Kim, V. Sainati, M. Schiavina, M. G. Murrali, B. Pan, J. J. Ferrie, C. M. Haney, R. Moons, A. Natalello, F. Sobott, E. J. Petersson, E. Rhoades, R. Pierattelli, I. Felli, K. A. Caldwell, G. A. Caldwell, E. S. Krol, H. Ischiropoulos. Scientific Reports, 2019, 9, 2937. Link
14. “A ‘Clickable’ photoconvertible small fluorescent molecule as a minimalist probe for tracking individual biomolecules” J. V. Jun, C. M. Haney, R. J. Karpowicz, Jr., S. Giannakoulias, V. M.-Y. Lee, E. J. Petersson, D. M. Chenoweth, Journal of the American Chemical Society, 2019, 141, 1893. Highlighted by JACS and in Chemical & Engineering News. Link
13. “Using a large ensemble FRET library with multiple probe pairs to drive Monte Carlo simulations of disordered α-synuclein.” J. J. Ferrie, C. M. Haney, J. Yoon, B. Pan, Y. Lin, Z. Fakhraai, E. Rhoades, A. Nath, E. J. Petersson. Biophysical Journal, 2018, 114, 53-64. Link
12. “Fluorescence spectroscopy reveals N-terminal order in fibrillar forms of α-synuclein.” C. M. Haney, E. J. Petersson, Chemical Communications, 2018, 54, 833-836. Link
11. “Multicolor protein FRET with tryptophan, selective coumarin-cysteine labeling, and genetic acridonylalanine encoding” J. J. Ferrie, N. Ieda, C. M. Haney, C. R. Walters, I. Sungwienwong, J. Yoon, and E. J. Petersson, Chemical Communications, 2017, 53, 11072. Link
10. “Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.” R. J. Karpowicz, Jr., C. M. Haney, T. S. Mihaila, R. M. Sandler, E. J. Petersson, V. M.-Y. Lee, Journal of Biological Chemistry, 2017, 292, 13648. Selected as an Editor’s Pick. Highlighted by Hasegawa and Suzuki. Link
9. “Site-specific fluorescence polarization for studying the disaggregation of α-synuclein fibrils by small molecules.” C. M. Haney, C. L. Cleveland, R. F. Wissner, L. Owei, J. Robustelli, M. Daniels, M. Canyurt, P. Rodriguez, H. Ischiropoulos, T. Baumgart, E. J. Petersson, Biochemistry, 2017, 56, 683. Article featured on the journal cover and in Biochemistry News & Views. Link
8. “Thermodynamic origin of α-helix stabilization by side-chain cross-links in a small protein.” C. M. Haney, H. M. Werner, J. J. McKay, W. S. Horne, Organic & Biomolecular Chemistry, 2016, 14, 5768. Link
7. “Comparison of strategies for non-perturbing labeling of α-synuclein to study amyloidogenesis.” C. M. Haney, R. F. Wissner, J. B. Warner, Y. J. Wang, J. J. Ferrie, D. J. Covell, R. J. Karpowicz Jr., V. M-Y. Lee, E. J. Petersson, Organic & Biomolecular Chemistry, 2016, 14, 1584. Selected by the editors as a 2016 Hot Article in Organic & Biomolecular Chemistry. Link
6. “Multiply labeling proteins for studies of folding and stability.” C. M. Haney, R. F. Wissner, E. J. Petersson, Current Opinion in Chemical Biology, 2015, 28, 123. Link
5. “Receptor-templated stapling of intrinsically disordered peptide ligands.” C. M. Haney, W. S. Horne, Organic & Biomolecular Chemistry, 2015, 13, 4183. Link
4. “Dynamic covalent side-chain cross links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers.” C. M. Haney, W. S. Horne, Journal of Peptide Science, 2014, 20, 108. Link
3. “Oxime side-chain cross-links in an α-helical coiled-coil protein: Structure, thermodynamics, and folding-templated synthesis of bicyclic species.” C. M. Haney, W. S. Horne, Chemistry – A European Journal, 2013, 19, 11342. Link
2. “Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links.” C. M. Haney, M. T. Loch, W. S. Horne, Chemical Communications, 2011, 47, 10915. Article featured on the journal cover. Link
1. “Identification of Hsp70 modulators through modeling of the substrate binding domain.” C. M. Haney, C. Schneider, B. Beck, J. L. Brodsky, A. Dömling, Bioorganic & Medicinal Chemistry Letters, 2009, 19, 3828. Link
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Research Funding
“Screening and Optimization of Peptides to Probe alpha-Synuclein Aggregates.” Summer Undergraduate Research and Creativity Award, Deferred to Fall 2020 semester, Funded September 2020, $5000.
“Virtual Screening and Experimental Validation of Small-Molecule Allosteric Modulators of Chaperone Proteins to Counter Protein Aggregation,” Charles L. Cahill Grant, University of North Carolina Wilmington, Funded January 2020, $5000.
“Generation of alpha-Synuclein Binding Peptides for Neuroimaging,” North Carolina Biotechnology Center, Funded April 2019, $16,670.
“Virtual Screening and Experimental Validation of Small-Molecule Allosteric Modulators of Chaperone Proteins to Counter Protein Aggregation,” Charles L. Cahill Grant, University of North Carolina Wilmington, Funded January 2020, $5000.
“Generation of alpha-Synuclein Binding Peptides for Neuroimaging,” North Carolina Biotechnology Center, Funded April 2019, $16,670.
Presentations & Posters
11. “Small Molecule Modulators of Chaperone Hsp70 for Amyloid Remodeling,” M. J. Weber, S. Le, C. M. Haney. 71st Southeastern Regional American Chemical Society Meeting in Savannah, GA. October 22nd, 2019, poster session.
10. “Structural Differentation of α-Synuclein Fibril Strains by Fluorescence Spectroscopy.” C. M. Haney, E. J. Petersson, 254th American Chemical Society National Meeting in Washington, D. C. August 24th, 2017, symposium talk.
9. “Fluorescent Labeling of α-Synuclein for Studying Aggregation, Propagation, and Strain Emergence.” C. M. Haney, R. J. Karpowicz, T. S. Mihaila, V. M.-Y. Lee, E. J. Petersson. Bioorganic Gordon Research Conference at Proctor Academy, Andover, NH. June 12th 2017, poster session.
8. “Fluorescent Labeling of α-Synuclein for Studying Aggregation, Propagation, and Strain Emergence.” C. M. Haney, Center for Neurodegenerative Disease Research, University of Pennsylvania, May 23rd, 2017.
7. “Monitoring Conformational Changes in α-Synuclein During Aggregation and Small Molecule Treatment.” C. M. Haney, J. J. Ferrie, T. Mihaila, M. Chang, J. Yoon, E. J. Petersson. Annual Marian S. Ware Research Retreat, Center for Neurodegenerative Disease Research in Philadelphia, PA, October 11th, 2016, poster session. 2nd Place poster prize.
6. “One Protein, Many Misfolds: Studies of Fibrillar Strains of α-Synuclein.” C. M. Haney, C. L. Cleveland, E. J. Petersson. 252nd American Chemical Society National Meeting in Philadelphia, PA. August 22nd, 2016, symposium talk.
5. “Studying Fibrillar α-Synuclein Through Fluorescent Labeling.” C. M. Haney, C. L. Cleveland, M. Chang, T. Mihaila, E. J. Petersson. Annual Institute on Aging Retreat, Philadelphia, PA. June 8th, 2016, poster session. Annual Chemistry-Biology Interface Retreat, Bryn Mawr College, Bryn Mawr PA. June 12th, 2016, poster session.
4. “Studying Amyloid Fibril Formation and Remodeling Using Fluorescently Labeled α-Synuclein.” C. M. Haney, R. F. Wissner, C. L. Cleveland, E. J. Petersson. 250th American Chemical Society National Meeting in Boston, MA. August 16th, 2015, poster session.
3. “Studying α-Synuclein Misfolding Through Förster Resonance Energy Transfer.” J. J. Ferrie, C. M. Haney, R. F. Wissner, E. J. Petersson. Annual Institute on Aging Retreat, Philadelphia, PA. May 5th, 2015, poster session. Best poster prize in the Basic Science category.
2. “Studying α-Synuclein Misfolding Through Förster Resonance Energy Transfer.” C. M. Haney, R. F. Wissner, E. J. Petersson. Biophysical Society 59th Annual Meeting in Baltimore, MD. February 8th, 2015, poster session.
1. “Bioorthogonal and Dynamically Reversible Cross-linking Strategies to Promote Peptide Folding and Stabilize Protein-protein Complexes.” C. M. Haney, M. Loch, W. S. Horne. 246th American Chemical Society National Meeting in Indianapolis, IN. September 9th, 2013, symposium talk.
10. “Structural Differentation of α-Synuclein Fibril Strains by Fluorescence Spectroscopy.” C. M. Haney, E. J. Petersson, 254th American Chemical Society National Meeting in Washington, D. C. August 24th, 2017, symposium talk.
9. “Fluorescent Labeling of α-Synuclein for Studying Aggregation, Propagation, and Strain Emergence.” C. M. Haney, R. J. Karpowicz, T. S. Mihaila, V. M.-Y. Lee, E. J. Petersson. Bioorganic Gordon Research Conference at Proctor Academy, Andover, NH. June 12th 2017, poster session.
8. “Fluorescent Labeling of α-Synuclein for Studying Aggregation, Propagation, and Strain Emergence.” C. M. Haney, Center for Neurodegenerative Disease Research, University of Pennsylvania, May 23rd, 2017.
7. “Monitoring Conformational Changes in α-Synuclein During Aggregation and Small Molecule Treatment.” C. M. Haney, J. J. Ferrie, T. Mihaila, M. Chang, J. Yoon, E. J. Petersson. Annual Marian S. Ware Research Retreat, Center for Neurodegenerative Disease Research in Philadelphia, PA, October 11th, 2016, poster session. 2nd Place poster prize.
6. “One Protein, Many Misfolds: Studies of Fibrillar Strains of α-Synuclein.” C. M. Haney, C. L. Cleveland, E. J. Petersson. 252nd American Chemical Society National Meeting in Philadelphia, PA. August 22nd, 2016, symposium talk.
5. “Studying Fibrillar α-Synuclein Through Fluorescent Labeling.” C. M. Haney, C. L. Cleveland, M. Chang, T. Mihaila, E. J. Petersson. Annual Institute on Aging Retreat, Philadelphia, PA. June 8th, 2016, poster session. Annual Chemistry-Biology Interface Retreat, Bryn Mawr College, Bryn Mawr PA. June 12th, 2016, poster session.
4. “Studying Amyloid Fibril Formation and Remodeling Using Fluorescently Labeled α-Synuclein.” C. M. Haney, R. F. Wissner, C. L. Cleveland, E. J. Petersson. 250th American Chemical Society National Meeting in Boston, MA. August 16th, 2015, poster session.
3. “Studying α-Synuclein Misfolding Through Förster Resonance Energy Transfer.” J. J. Ferrie, C. M. Haney, R. F. Wissner, E. J. Petersson. Annual Institute on Aging Retreat, Philadelphia, PA. May 5th, 2015, poster session. Best poster prize in the Basic Science category.
2. “Studying α-Synuclein Misfolding Through Förster Resonance Energy Transfer.” C. M. Haney, R. F. Wissner, E. J. Petersson. Biophysical Society 59th Annual Meeting in Baltimore, MD. February 8th, 2015, poster session.
1. “Bioorthogonal and Dynamically Reversible Cross-linking Strategies to Promote Peptide Folding and Stabilize Protein-protein Complexes.” C. M. Haney, M. Loch, W. S. Horne. 246th American Chemical Society National Meeting in Indianapolis, IN. September 9th, 2013, symposium talk.
